My Dermatologist recommended this shampoo to me over 10 years ago and I have been using it off and on since. My scalp psoriasis comes and goes depending on the season and the frequency of chemical hair treatments I have ie: perms, hi-lites, etc. When my scalp is really bad it actually has large flakes of dry skin fall off and has been known to weep and bleed...It`s bad! But if I remember to wash my hair more often, as in every day,and use this Glycolix shampoo, I can keep it under control quite well! I love to use this with the Derma Topix Hair Repair Conditioner. It has the most delightful, light and clean scent! Actually - I just picked up another bottle today and my scalp is improved already!